Anti-Human CD2 Recombinant Antibody (TAB-104)
CAT#: TAB-104
Recombinant monoclonal antibody to CD2. It is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
Tested Data
Gene Expression
ELISA
Figure 1 Anti-Human CD2 Antibody (TAB-104) in ELISA
ELISA analysis of TAB-104 was performed by coating with Recombinant Human CD2 Protein (His Tag). Then blocked with BSA and incubated with Anti-Human CD2 Antibody (TAB-104). The HRP-conjugated goat anti-Human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
WB
Figure 2 Anti-Human CD2 Antibody (TAB-104) in WB
Western blot analysis of TAB-104 was performed by loading Recombinant Human CD2 Protein (His Tag) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-104 and HRP Goat Anti-Human IgG as a secondary antibody. Chemiluminescent detection was performed.
Lane 1: Non-Reduced Antigen (1 μg)
Lane 2: Reduced Antigen (1 μg)
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Subcellular Location
Figure 1 IF staining of human cell line JURKAT
Immunofluorescent staining of human cell line JURKAT shows localization to nucleoplasm, plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/2036_G3_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_8_8.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_4_8.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (HDLM-2, JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
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Specifications
- Immunogen
- Human CD2 recombinant protein
- Host Species
- Rat
- Derivation
- Humanized (from rat)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, FuncS, Neut, IF, ICC
- Related Disease
- Psoriasis
Product Property
- Purity
- >95%, by SDS-PAGE with silver staining, under reducing conditions.
- Storage
- At -20°C for one year.
Applications
- Application Notes
- The CD2 antibody has been reported in applications of Cyt.
Target
- Alternative Names
- Siplizumab;288392-69-8;MEDI-507;CD2;CD2 molecule;CD2 antigen (p50), sheep red blood cell receptor , SRBC;T-cell surface antigen CD2;LFA-3 receptor;rosette receptor;erythrocyte receptor;lymphocyte-function antigen-2;T-cell surface antigen T11/Leu-5;CD2 ant
- Gene ID
- 914
- UniProt ID
- P06729
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-104, RRID: AB_3111812)
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Biosimilar Overview
Please refer to Siplizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Siplizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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